Turns out I only need to do this (source: Martinec)

src/monitor.rs

@@ -92,10 +92,9 @@ impl Monitor {
 				if key == KeyCode::Char('r') && mods == KeyModifiers::CONTROL {
 					stdout.write_all(b"\r\n*** Reboot ***\r\n")?;
 					port.set_dtr(true)?;
-					port.set_rts(true)?;
+					port.set_rts(false)?;
 					std::thread::sleep(Duration::from_millis(10));
 					port.set_dtr(false)?;
-					port.set_rts(false)?;
 					continue
 				}
 

src/target.rs

@@ -244,10 +244,9 @@ impl Target for PhysicalTarget {
 impl Drop for PhysicalTarget {
 	fn drop(&mut self) {
 		let _ = self.port.set_dtr(true);
-		let _ = self.port.set_rts(true);
+		let _ = self.port.set_rts(false);
 		std::thread::sleep(Duration::from_millis(100));
 		let _ = self.port.set_dtr(false);
-		let _ = self.port.set_rts(false);
 	}
 }